Modeling Protein Stability
نویسندگان
چکیده
منابع مشابه
Modeling protein stability with Gaussian processes
ii Abstract (in Finnish) iiiin Finnish) iii
متن کاملModeling backbone flexibility improves protein stability estimation.
In designing mutagenesis experiments, it is often crucial to know how certain mutations will affect the structure and thermodynamic stability of the protein. Here, we present a methodology, Eris, to efficiently and accurately compute the stability changes of proteins upon mutations using our protein-modeling suite, Medusa. We evaluate the stability changes upon mutations for 595 mutants from fi...
متن کاملProtein Stability, Folding, Disaggregation and Etiology of Conformational Malfunctions
Estimation of protein stability is important for many reasons: first providing an understanding of the basic thermodynamics of the process of folding, protein engineering, and protein stability plays important role in biotechnology especially in food and protein drug design. Today, proteins are used in many branches, including industrial processes, pharmaceutical industry, and medical fields. A...
متن کاملModeling and Analysis of Handling-Stability of Passenger Cars
A nonlinear model consisting “yaw, roll, longitudinal, lateral and pitch” has been developed in which, tire and suspension characteristics have been considered. Tire model is based on the elliptic concept and tire Calspan data. According to this tire model, cornering force and aligning moment are computed as a function of slip and camber (inclination) angles, normal load, tire adhesion characte...
متن کاملA Proposed Modeling Method in Finite Element Slope Stability Analysis
Limit-equilibrium method (LEM) and finite element method (FEM) with strength reduction method (SRM) techniques are the most widely used analysis tools in slope stability assessment. Recently, researchers have reported that both factor of safety (FOS) values and failure surfaces obtained from LEM and FEM are generally in good agreement, except in some particular cases. In this paper, the FOS and...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2010
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2009.12.3476